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KMID : 0881720210360060488
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Journal of Food Hygiene and Safety
2021 Volume.36 No. 6 p.488 ~ p.492
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Control Effect of Staphylococcus aureus by Co-Treatment of Nisin and a Bacteriophage
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Kim Seon-Gyu
Moon Gi-Seong
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Abstract
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One of the well characterized bacteriocins, nisin, shows strong antimicrobial activity against pathogenic bacteria such as Listeria monocytogenes and Staphylococcus aureus. This study evaluated the synergistic effect of commercial nisin and SAP84 bacteriophage on S. aureus. Nisin showed antimicrobial activity against S. aureus KCTC 3881 in a dose-dependent manner. Eighteen IU/mL of the nisin decreased 4.03 Log CFU/mL of the strain in MRS broth after six hours compared with the controlled subject. On the other hand, the same dose of the nisin decreased 5.54 Log CFU/mL when co-treated with 0.1 MOI of the bacteriophage SAP84. Furthermore, the combination of nisin and SAP84 was successfully applied for controlling the S. aureus strain in lettuce.
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KEYWORD
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Nisin, Bacteriophage, Staphylococcus aureus, Antimicrobial activity, Synergistic effect
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